Medically assisted reproduction within families: A position paper by the European Society of Human Reproduction and Embryology

The European Society of Human Reproduction and Embryology (ESHRE) has published today (Thursday) a position paper related to intrafamilial medically assisted reproduction (IMAR).This particular type of assisted reproduction can raise various ethical and controversial issues, due to the involvement of a family member as a third party.The ESHRE Task Force on Ethics and Law acknowledges the benefits that IMAR may bring to those choosing this approach and concludes that certain forms of IMAR are morally acceptable under certain conditions. The group advises to evaluate each request for IMAR individually, based on four ethical principles in health care: the respect for autonomy, beneficence and non-maleficence and justice. The Task Force explains that the right for individual autonomy is elementary: any individual should have the principle of choice with whom to reproduce.
It is understandable that couples wish to preserve some sort of genetic identity with the child, and hence may wish to choose a donor in the family. IMAR may facilitate a child’s access to its biological roots and enable it to have contact with the donor or the surrogate mother. Often faced with no realistic alternatives due to long waiting times or lack of donors, IMAR may also be the only option available to these patients.The ESHRE group recommends that fertility doctors should take into account the relevant regulations in their country when they assist a couple with IMAR. In some countries IMAR is illegal and the relevant laws against incest and consanguinity apply to protect the offspring from genetic risks and to avoid possible social disruptions and conflicts. “Doctors should assess any possible psychosocial and medical risks related to the treatment,” says Dr. Wybo Dondorp, deputy coordinator of the Task Force. “Doctors must therefore consider the principles of beneficence and non-maleficence together and aim at producing net benefit over harm for all parties involved.
”Potential risks may affect several parties, including the future child. These risks can arise from intrafamilial conflict if parents feel threatened in their parental role or if they have different views from the collaborators on how the child should be informed of its genetic origins. Especially in cases of intergenerational IMAR, there are concerns that the child may be confused about his role in the family. The possible pressure on the donor or surrogate to collaborate can also lead to psychological problems. Adequate information on possible risks should be given to all parties. This includes both combined and separate counseling of recipients and collaborators to assess the voluntariness of the donation and to reduce potential conflict situations.According to the principle of justice, doctors should treat similar cases in the same way. So if sister-to-sister oocyte donation is accepted so should brother-to-brother sperm donation. The justice principle also applies where IMAR may circumvent unjust exclusion if waiting times for donors are long or the treatment costs are too high without intrafamilial donors.It is of paramount importance that recipients and collaborators give their informed consent.
The ESHRE group is in favour of disclosure of information to the child if other relatives are aware of the familial collaboration. The counselor should offer support in any case and various strategies may be equally justified; while some would give priority to the child’s right to know, others would be more concerned about the risk of confusion and accept a parental preference for secrecy.Doctors should not accept a minor relative as a gamete donor or a surrogate. In the case of intended surrogacy the Task Force considers parenthood by the surrogate to be a precondition in order to collaborate in IMAR.The paper gives special attention to (rare) cases of consanguineous IMAR, involving the mixing of gametes of persons that are genetically closely related. “The Task Force considers consanguineous IMAR between up to third degree relatives as acceptable in principle, subject to additional counseling and risk-reduction,” says Professor Guido de Wert, coordinator of the ESHRE Task Force. “Here, genetic counseling is appropriate to assess the increased risk of conceiving a child affected by a serious recessive disease.” Part of adequate genetic counseling and good clinical practice in such cases is to offer carrier screening for those disorders that are more prevalent in the particular ethnic group. Given that fertility specialists have a co-responsibility for the welfare of the child, it may be morally justified to offer such genetic testing as a condition for access to assisted reproduction.
The group concludes that in some situations IMAR is morally acceptable as long as counseling of recipients and collaborators is applied in order to reduce potential psychosocial and medical risks. First-degree intergenerational IMAR needs special scrutiny, also in view of the increased risk of undermining autonomous choice. First- and second degree consanguineous IMAR is at odds with the spirit of anti-consanguinity and anti-incest legislation in most countries and should not be offered. The group encourages more research into the psychosocial implications of IMAR to contribute to adequate and moral guidance. BackgroundDepending on the degree of familial closeness, there can be different types of IMAR. The relationship between donor and acceptor can be either first degree such as between siblings or parents and children, second degree such as for example between uncle and niece and third degree such as between cousins. The collaboration between the different parties (those providing donor gametes, a surrogate uterus or both, and the acceptor) can be in the same generation (such as for example sisters) or between generations (for example mother and daughter).
IMAR can involve different scenarios such as sperm, egg or embryo donation by a family member and/or surrogacy which can be full surrogacy (surrogate provides the eggs) or partial surrogacy (surrogate carries the IVF embryo). In practice, a common form of IMAR is sister-to-sister oocyte donation. Most cases of IMAR are non-consanguineous. Consanguinity, which is defined as reproduction using gametes (eggs and sperm) from individuals that are closely related genetically, may lead to an increased genetic risk for the future child. The magnitude of this risk depends on the degree of consanguinity. In any general population the risk of having a child with a handicap or a major disease is 3%. In third degree consanguinity, the risk is estimated to be around 5-6%. If the applicant and the intended collaborator carry the same disease, there is a 25% risk of conceiving a child affected with that particular condition.

**The paper is published online on 20 January 2011 in the journal Human Reproduction: doi:10.1093/humrep/deq383. The full paper is available on request.